In the 2010s, he appeared in many American films and television series, such as Jack and Jill, Girl in Progress, Rob!, and Miracles from Heaven. Apart from appearing in live-action roles, Derbez has appeared in animated films including. Derbez provided the Spanish dubs for many characters in the Spanish versions of American films including Dr. Dolittle, Mulan, 102 Dalmatians, and the Shrek franchise.
His feature film Instructions Not Included which he directed, co-wrote, and starred in became the most successful Spanish-language film in the U.S. and worldwide and broke numerous box-office records, earning more than $100 million worldwide. Derbez also appeared in the film How to Be a Latin Lover alongside Salma Hayek and Kristen Bell and in the Paramount film Dora and the Lost City of Gold.
Derbez resides in Los Angeles, is married to Alessandra Rosaldo, and has 4 children.

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