Charles Salvatore Panozzo (born September 20, 1948) is an American musician best known as a co-founder of the rock band Styx. He is currently a part-time bass player in the band, sharing bass duties with Ricky Phillips. Panozzo suffers from HIV, which prevents him from full-time participation.
Panozzo grew up in a working-class Italian Catholic neighborhood in South Side, Chicago. At the age of 7, Panozzo and his fraternal twin brother, drummer John Panozzo, who died in July 1996, took music lessons from an uncle. He attended Catholic schools. Since age 7, Panozzo realized that he was gay.
In 1961-1962, Panozzo founded Styx with his brother and singer/keyboardist Dennis DeYoung. Panozzo received a degree in art education and taught art at the high school level.

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