Luke was born in Jersey City, New Jersey, the son of Marjorie Dixon, a pianist, and Maurice Luke, a former actor. His father is from Georgetown, Guyana. He attended Henry Snyder High School and graduated from Linden High School.
Luke played one of the four male leads in Spike Lee's 2008 war film Miracle at St. Anna, replacing Wesley Snipes, who had to leave the film due to his highly publicized tax problems.
Luke played a small role as a nurse in the 1999 episode "White Collar" of the sitcom The King of Queens, and appeared on the NBC show Trauma. He played one of the group members of Mayhem in the Moesha episode "Mayhem at the Jam Esp" (March 19, 2001).

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