Guillén has appeared in recurring roles in television series such as Alistair Delgado on Huge, Cousin Blobbin on The Thundermans, George Reyes in Eye Candy, and Benedict Pickwick on The Magicians. He also appeared in the 2013 film The Internship. He plays the role of Guillermo, the vampires\' human familiar, in the FX television series What We Do in the Shadows.\n', '

TheWrap included Guillén in a list of "2019 Emmy Contenders". Hank Steuver, in his review of What We Do in the Shadows in The Chicago Tribune, stated that Guillén "provides at least half the big laughs" in the show.\n', '

Guillén identifies as queer.\n', '

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