Stamberg was born in Washington, D.C., the son of journalist Susan Stamberg and Louis C. Stamberg. He attended the University of Wisconsin–Madison.
Stamberg appeared in numerous television shows, including Nashville, Law & Order, CSI: Miami, Grey's Anatomy and Parenthood. He also appeared in the Lie to Me pilot. Stamberg appears as S.W.O.R.D. Director Tyler Hayward in the WandaVision Marvel series on Disney+. His film appearances include Fracture, Must Love Dogs and Kate & Leopold.
In 2020, Stamberg appeared as a guest on the Studio 60 on the Sunset Strip marathon fundraiser episode of The George Lucas Talk Show.

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