Kathryn Meisle was born in Philadelphia. Her grandfather, Matthew Müssle, originally from Baden-Baden, Germany, settled in Philadelphia in 1848. After naturalization in 1856 he changed his surname to Meisle.
As a child, her father urged her to take piano lessons, sometimes taking multiple lessons a week. When she was fifteen, she was heard by a choir director who offered her a position. Thereafter she commenced vocal study. One of her vocal teachers was Enrica Clay Dillon.
In 1917 she married Calvin M. Franklin (born 1887), an agent who became her manager.

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