A 30-year-old rookie, Main began his big league career on April 18, 1914, for the Tigers. With them, he appeared in 32 games, starting 12 of them. He went 6–6 with a 2.67 ERA, completing five games and saving three. His three saves ranked sixth in the league.\n', '

The following season, he became the second Tiger pitcher to jump to the short-lived Federal League, the first being Ed Willett. He played for the Packers that season. Although his ERA of 2.54 was third best on the team and he gave up only 181 hits in 230 innings, his record was only 13–14. He had the worst record on the team among all pitchers with at least 25 games started. Despite that, his 1.113 WHIP was fifth best in the league, and his 7.08 hits per nine innings ratio ranked second. His three saves were eighth best in the league that season. On August 16 of that season, he threw the first no-hitter in Federal League Park history.\n', '

Main did not play in the Major Leagues in either 1916 or 1917, but in 1918 he appeared in eight games for the Phillies. Making four starts, he went 2–2 with a 4.63 ERA. He played his final big league game on June 29.\n', '

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