Palicki was born in Toledo, Ohio, the daughter of Nancy Lee (née French) and Jeffrey Arthur Palicki. She has an elder brother Eric, a comic book writer who influenced her interest in comics.\n', '
She was a series regular on the first three seasons of NBC\'s drama series Friday Night Lights from 2006 to 2009, portraying Tyra Collette. In early 2011, she returned for the final two episodes of the series.\n', '
In 2003, Palicki also appeared as Judy Robinson in John Woo\'s unsold pilot, The Robinsons: Lost in Space. In 2006, she also appeared in The WB pilot Aquaman as the evil Nadia. The pilot was not picked up for series by the CW network, a result of The WB and UPN network merger, which occurred while the pilot was being filmed. She appeared as Kara/Lindsey Harrison in the season 3 finale of Smallville. Palicki appeared in Supernatural as Jessica Moore, Sam Winchester\'s doomed girlfriend who is killed by a demon in its pilot episode. The character reappears in the Supernatural season 2 episode, "What Is and What Should Never Be", and the season 5 episode "Free To Be You and Me."\n', '