Weis grew up in Bethpage, New York, and graduated from Farmingdale High School in 1955. He was a high school teammate of pitcher Jack Lamabe, with whom he was teammates on the Chicago White Sox in 1966 and 1967.\n', '

Weis joined the United States Navy after high school. It was playing baseball at Naval Station Norfolk where Weis caught the eye of the White Sox, with whom he signed as an amateur free agent in 1959. After four years in their farm system, in which he batted .266 with fifteen home runs and 159 runs batted in, Weis received a September call-up in 1962, batting only .083 in seven games.\n', '

Weis played 99 games as a utility infielder in his rookie season of 1963, with 48 of those games at second base and 27 at shortstop. Following the trade of Nellie Fox during the off-season, Weis became more of a second baseman in 1964, although he still made nine appearances at shortstop, including 4 starts. He batted .247 and established career highs with 81 hits and 22 stolen bases, second in the American League to Hall of Famer Luis Aparicio. That year, the White Sox finished second in a tight American League pennant race, one game behind the New York Yankees and one game ahead of the Baltimore Orioles.\n', '

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