Lopez was selected by the Tampa Bay Devil Rays in the second round (48th pick overall) of the expansion draft in 1997. In 1998, Lopez had a career best 2.60 ERA in 54 games for the expansion team Devil Rays.\n', '

In 1999, his ERA rose to 4.64 while appearing in 51 games. In 2000, Lopez was a swingman, appearing in 45 games while also starting 24 games for the Devil Rays. He won a career-high 11 games while throwing 4 complete games and 2 saves.\n', '

The Devil Rays then traded Lopez to the Arizona Diamondbacks in 2001 after going 5-12 in 20 starts for the Devil Rays. With the Diamondbacks, Lopez recorded 4 wins in 13 starts. Between both clubs, Lopez finished the 2001 season with a major league leading 19 losses, although not officially leading any league due to him having been traded and splitting time between both leagues. He was part of the 2001 World Series winning team over the New York Yankees. Lopez was criticized for his poor performance on the team, which led him to sign with the Atlanta Braves at the end of that season. Lopez was 1-4 in 55.2 innings for the Braves.\n', '

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