Schuch was born in 1985 in Jena, East Germany. He is the younger brother of actress Karoline Schuch. He studied acting at the University of Music and Theatre Leipzig from 2006 to 2010.
Schuch made his film debut in Robert Thalheim's Westwind. In 2012, he played his first film starring role as Alexander von Humboldt in Detlev Buck's Measuring the World based on Daniel Kehlmann's novel of the same name.
He is the only actor to win the German Film Award in two categories as lead and supporting actor at the same award ceremony. In 2020, he won both awards for the films System Crasher and Berlin Alexanderplatz. Two years later, he won again as Best Actor for the Film Dear Thomas.

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