Facchinetti is the daughter of singer and keyboard player Roby Facchinetti, a member of the Italian group I POOH. Her younger brother is Francesco Facchinetti.
Facchinetti spent four years in art college in her hometown of Bergamo before settling in Milan, graduating from the Istituto Marangoni in 1995.
From 1994, Facchinetti worked for seven years with Miuccia Prada, first as designer at Prada and later as fashion coordinator for women's and men's at Miu Miu, succeeding Stefano Pilati.

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