At age eighteen, Colomé signed with the Tampa Bay Devil Rays as an amateur free agent in March 2007. The Rays added him to their 40-man roster on November 18, 2011.\n', '

The Rays promoted Colomé to the major leagues on May 29, 2013. He started 3 games, posting a 2.25 earned run average (ERA).\n', '

On March 24, 2014, Colomé was suspended 50 games for failing a random drug test. Colome ended the year 2-0 with a 2.66 ERA in 5 games, 3 of which were starts. Colomé saw his first significant playing time in 2015, most of it due to a switch to the bullpen, where he finished with 43 appearances and a 3.94 ERA.[citation needed]\n', '

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