In addition, she regularly appears as supporting characters in films directed or produced by her older brother Sean Anders, namely Never Been Thawed, Sex Drive, Daddy's Home 2, Instant Family, Countdown and Spirited, and has also had roles in a handful of other films such as The Stepford Wives, Return to Zero, Is That a Gun in Your Pocket? and Nancy Drew and the Hidden Staircase.
Andrea Anders was born in Madison, Wisconsin on May 10, 1975, the third child of Terrance and Sally Anders. She was raised in DeForest, Wisconsin with her sister Torri and her brother Sean, where she attended the DeForest Area High School, graduating in 1993. She went on to study acting at the University of Wisconsin–Stevens Point, receiving her bachelor's degree in fine arts in 1997. She then moved to New Jersey to study at Rutgers University's Mason Gross School of the Arts, earning a Master of Fine Arts in 2001. In addition, she trained in the Meisner technique under Maggie Flanigan and credits the teacher with her continued work as an actress.
In 2001, Anders began her career in theatre. She was an understudy for Mary-Louise Parker in the Broadway production of Proof and later played the part of Elaine Robinson in The Graduate. She also appeared in On the Jump at the Arena Stage, New Doors at the Guthrie Theater, Debbie Does Dallas: The Musical and two New York Stage & Film productions: Cold/Tender and New World Rhapsody.

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