Matarazzo was born in São Paulo, Brazil but raised mostly in Miami, Florida as part of a diverse, multilingual family where he grew up speaking Portuguese, English and Spanish. His mother Jade Matarazzo is a leader at the forefront of the Latino arts community both for her own work and helping expose other international artists to American audiences. Although he had performed on stage since childhood, Matarazzo only decided to branch into film after seeing River Phoenix in Stand by Me.
He studied in Thorpe, Surrey near London at the American School in England (TASIS) as well as spending some time at University of the Arts (Philadelphia) and the California Institute of the Arts (CalArts) in Los Angeles.
In Los Angeles, Matarazzo, landed roles in a series of festival circuit short films that ran at Tribeca Film Festival and Cannes Film Festival. He went on to play small roles in several television shows including HBO's Girls, MTV's Faking It, Criminal Minds on CBS, and Speechless on ABC.

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