Santino grew up in River North, Chicago. Raised by a single mother, he lived in Section 8 housing. He went to high school at Naperville North High School in Naperville, Illinois. He also attended Arizona State University.
On I'm Dying Up Here, he played Bill Hobbs, a talented, popular comedian who sabotages himself with a bitter attitude and negative outlook on life. Currently he stars in the series Dave, which tells the fictionalized story of rapper Lil Dicky. Santino portrays Dave's roommate and manager. In 2017, he released a Showtime special called "Home Field Advantage" 1. He also played a recurring character in the NBC drama This Is Us, a producer of the fictional sitcom The Manny.
Santino produces and hosts a podcast, Whiskey Ginger, where he interviews friends in the entertainment industry as they reflect on their past while sipping whiskey. In 2020, Santino began co-hosting the Bad Friends podcast with Bobby Lee.

Return to Andrew Santino Autograph Profile