Seminick was born in Pierce, West Virginia to Ukraine immigrant parents, but moved to Muse, Pennsylvania when Andy was two. He was contracted as an amateur free agent in 1941 by the Pittsburgh Pirates. Seminick led the Appalachian League in 1942 with 15 home runs and 202 total bases, and was among the league leaders in batting average. In 1943, he had a .303 batting average with the Knoxville Smokies of the Class-A Southern Association, and was purchased by the Philadelphia Phillies.\n', '

At the age of 23, Seminick made his major league debut on September 14, 1943. By 1945, the Phillies were using Seminick in a platoon system alongside veteran catcher Gus Mancuso. While he could hit for power, his defensive skills were below average, as he led the National League in errors in 1946, 1948 and 1949. Phillies manager Eddie Sawyer assigned Phillies coach and former catcher Cy Perkins to tutor him, which helped improve his defensive skills. He was voted by baseball fans to be the starting catcher for the National League in the 1949 All-Star Game, mostly for his reputation as a hitter.\n', '

On June 2, 1949, the Phillies hit five home runs during the eighth inning in a 12–3 victory over Cincinnati at Shibe Park, tying the major league mark set by the 1939 New York Giants. Seminick hit two home runs in the inning, while Del Ennis, Willie Jones and Schoolboy Rowe had one each. Jones added a triple as Granny Hamner\'s double jumped the extra bases total to 18, still a record. Seminick collected three home runs overall.\n', '

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