Sisco was the Chicago Cubs second-round pick in the 2001 Major League Baseball draft. He was selected to the Northwest League all-star team and short season A All-Star team as well as being named the short season player of the year, in 2002 with the Boise Hawks, when he was 7–2 with a 2.43 ERA in 14 starts.\n', '

Sisco was the second pick in the 2004 Rule 5 draft, taken by the Kansas City Royals from the Cubs organization. The Royals converted him to a relief pitcher. He made his Major League debut on April 4, 2005 against the Detroit Tigers, allowing two runs in 2 innings. Under the terms of Rule 5, Sisco remained on the Royals major league roster for the entire 2005 season so that he would not have to be offered back to the Cubs for $50,000. Sisco posted a 3.11 ERA in his rookie season for the Royals, but after struggling during the 2006 season, the Royals sent Sisco to Triple-A Omaha. They recalled him to Kansas City on August 8. His ERA rose to 7.10 in 2006.\n', '

On December 16, 2006, Sisco was traded to the Chicago White Sox for Ross Gload. He appeared in 19 games for the White Sox, with an 8.36 ERA in 2007 and also made 23 appearances (15 starts) for the AAA Charlotte Knights.\n', '

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