Lopez was first signed by the Seattle Mariners on July 3, 1997 and made his Major League debut on April 2, 2003 after being selected by the Toronto Blue Jays on December 16, 2002 as a Rule 5 draftee. He made 72 appearances in 2003 for the Blue Jays, recording 14 saves and posting a 3.42 ERA over ​73 2⁄3 innings.\n', '

In 2004, Lopez was still in Toronto where he pitched only 21 innings in 18 appearances. He was a member of the Colorado Rockies, Los Angeles Dodgers, Philadelphia Phillies and San Diego Padres organizations from 2005–2006, mostly as a Minor League player. Lopez signed with the Detroit Tigers before the 2007 season.\n', '

In 2008, after spending most of the season with the Tigers, Lopez was sent down to Toledo when Fernando Rodney was activated from the disabled list. Lopez was called up to Detroit July 2 when Zach Miner was sent to Toledo. Although his ERA on the season was a comparatively low 3.55, he allowed 50.9% of inherited runners to score, the second-highest in the American League. Lopez became a free agent after the 2008 season when the Tigers declined to offer arbitration.\n', '

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