Romans was originally inspired to pursue acting while watching her older sister play Ruth in her high school production of A Raisin in the Sun. She studied theater at Pace University, graduating in 2015.
In 2017, she won the Los Angeles Drama Critics Circle Award for Lead Performance in the play Rotterdam, in which she plays a character undergoing gender transition in conjunction with a partner who is struggling with coming out to her parents as a lesbian. In 2020, Romans replaced Lashana Lynch in the lead role of Agent 355 in the television adaptation of the comic book series Y: The Last Man. The series premiered in 2021.

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