Born in Houston, Texas, to a Jewish family, Hoffman lived most of his childhood in Lexington, Kentucky, attending Henry Clay High School. He attended Columbia University, where he studied writing and music production and subsequently worked in the field of dance music. He graduated from Columbia in 1999.
He had previously met Jake Shears—then still known as Jason Sellards—through a childhood friend, and Hoffman asked Shears to provide vocals for his tracks. When Hoffman moved to New York to study writing at Columbia, the duo officially joined forces and took stage names to become the first two members of Scissor Sisters in 2001. At the time, the band was just a combination of Babydaddy's music and Shears's vocal and visual performances. The band logo was designed by Babydaddy.
Since then, the band has grown and recruited further members, in the process expanding its original musical style to cover the rock, disco and dance music genres.
Babydaddy plays a number of instruments including keyboards, guitar, bass and banjo; he and Shears are the main lyricists for the band. The two also wrote the hit single "I Believe in You" for Kylie Minogue, as well as the title track from her documentary White Diamond. Babydaddy has also co-produced with other artists including Tiga and Xavier and has produced remixes (alongside Jake Shears under the Scissor Sisters moniker) for Pet Shop Boys, The Ones and Blondie.
In 2010, Babydaddy remixed disco icon Amanda Lear's single "I'm Coming Up".
In 2016, Hoffman produced and co-wrote alongside Dev Hynes and Nicola Roberts "Ghetto Boy" for Tinashe's second studio album Nightride.

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