Pfeffer attended the University of Illinois. He made his MLB debut on April 15, 1905 for the Chicago Cubs and had a 4-4 record for them that season. He missed out on the 1906 World Series, going to Boston, where he had his most active season with a record of 13-22 for the 1906 season. He finished second in the National League that season in complete games and strikeouts.\n', '

Early the following season, Pfeffer pitched a no-hitter on May 8, 1907, with the Boston Doves defeating Cincinnati 6-0. The Doves would later become known as the Boston Rustlers and then eventually Boston Braves.\n', '

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