At the age of 17, Clymer appeared in three games for the Philadelphia Athletics of the American Association. In 11 at-bats as a Major League player, he did not collect a hit, but did have one base on balls and one stolen base.
Clymer went on to play 18 seasons in the minor leagues (1891–1906) and was a minor league manager for approximately 29 years (1898–1932). He was the second minor league manager with more than 2,000 wins. Clymer died at the age of 63 in his hometown of Philadelphia, and is interred at North Cedar Hill Cemetery.

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