Humphreys\' pro pitching career began in the Tigers\' organization in 1958 and lasted through 1971. After trials with Detroit (1962) and St. Louis (1963), Humphreys was recalled from the Triple-A Jacksonville Suns in July 1964, and worked in 28 games out of the Redbird bullpen. He won his only two decisions (both coming in during the September pennant race) and posted two saves with a low 2.53 earned run average as St. Louis overcame the faltering Philadelphia Phillies to win the National League championship. In Game 6 of the 1964 World Series, he worked the ninth inning and retired the New York Yankees in order; it was Humphreys\' only post-season appearance. The Cardinals won the Series\' deciding seventh game a day later. \n', '

Humphreys was traded to the Cubs just prior to the 1965 campaign. In his only season with Chicago, he appeared in 41 games and again posted a 2–0 record. Then, prior to 1966, he was traded to the Senators, where he played four full years and part of a fifth. In 214 games pitched as a Senator, he compiled a 21–15 record with 14 saves. Released by Washington in June 1970, he caught on with Milwaukee, where he finished his MLB career and was credited with three more saves.\n', '

All told, Humphreys compiled a 27–21 record with 20 saves and a 3.36 earned run average in 319 major league appearances, all but four of which came as a relief pitcher. In 566 innings pitched he allowed 482 hits and 219 bases on balls. He struck out 364.\n', '

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