Her uncle, John Zacherle, was an American television host, radio personality and voice actor known for his long career as a television horror host broadcasting horror films in Philadelphia and New York City in the 1950s and 1960s.[citation needed]
Zacherle attended Syracuse University and majored in Illustration. After college, her first job was with Rust Craft Greeting Cards in Dedham, Massachusetts. At Rust Craft she worked in humorous cards and studio art, eventually becoming Art Director in charge of special projects. After nine years Zacherle left Rust Craft just after it was purchased by Norcross.
She had performed freelance work for Hasbro Toy Company since the mid-1970s and they had a standing offer of a full-time position for her if she ever wanted it. She took them up on the offer and joined Hasbro as an Illustrator in Research and Development at the company headquarters in Pawtucket, Rhode Island in 1980.

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