DuBois attended Reed-Custer High School in Braidwood, Illinois from 1981-1985. On Tuesday, June 6, 1985, DuBois ended an All-American high school pitching career with a 5-0 win over Litchfield (IL) High School during the Illinois Class A State Championship Title Game. In the Comets' 5-0 triumph over Litchfield, DuBois struck out 12 and came within one slip of pitching his second no-hitter in three tournament appearances. He threw 75 pitches in the state title game, 57 of them strikes. In one stretch, he struck out four batters on 12 pitches.
In 13 2/3 innings, he struck out 29 batters, walked three, allowed a blooper hit and even picked two men off first base. Minutes after the title game, DuBois found out he had been selected by the Baltimore Orioles in the fourth round of the free-agent draft.
DuBois' struck out 226 batters in 1985. It remains the all-time highest number of strikeouts during one season in Illinois High School Association's (IHSA) baseball history. During the 1985 season, DuBois pitched 109 innings, recorded an ERA of 0.06 with 3 no-hitters.

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