Palmer started her performing arts career dancing professionally for the shows "Jubilee" at Bally's Las Vegas and “X Burlesque” at Flamingo Las Vegas. After a car accident left Brittney bed-ridden she started working on her art before moving to Los Angeles and studying art history and classic portraiture working with acrylics, oils, and aerosols at the University of California, Los Angeles. Various exhibits have featured her work at institutions and galleries in Los Angeles, Miami, New York, Hong Kong and Milan.[citation needed]
On April 19, 2011, Palmer appeared on YouTube opposite model Jo Garcia, in a Mortal Kombat themed video, which has, as of September 2013, garnered over 600,000 hits. In 2012 Palmer appeared on the cover of the March issue of Playboy, making her the third ring girl to do so, preceded by Rachelle Leah and Arianny Celeste. At the 2012 World MMA Awards, Palmer was awarded Ring Card Girl of the Year, prevailing over Arianny Celeste for the 2012 award while simultaneously ending Celeste's winning streak.
Palmer has raised over $100,000 in donations through her paintings with some of the biggest organizations, charities, and auctions in the World, most notably the AMFAR Galas in Milan, Hong Kong, NYC and Sardinia. She has been an artist ambassador with UNICEF, Steven Tyler of Aerosmith‘s Janie’s Fund, Generation Cure, and Lady Gaga‘s Born This Way Foundation. Palmer has exhibited her paintings alongside influential artists including Pablo Picasso, Damien Hirst, Kaws, Ai Weiwei, Mr Brainwash, Ellen Von Unwerth and Andy Warhol.

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