Drafted by the Chicago Cubs in the 20th round of the 2000 MLB amateur draft, Pignatiello would spend seven seasons in various ranks within the farm system before being promoted in 2007, his eighth season in professional baseball. In 2003, he led the Florida State League with a career-high 140 strikeouts in 156.1 innings for the Daytona Cubs.\n', '

Pignatiello was called up by the Cubs on August 14, 2007, due to the need for left-handed relievers in the bullpen. Two days later, he made his major league debut against the Cincinnati Reds and pitched one scoreless inning of relief of a 12-4 victory.\n', 'In March, 2009 Carmen was signed to a minor league contract with the Minnesota Twins. Then released by the Twins, Pignatiello signed with the Schaumburg Flyers for the 2009 season as a starter, which saw him have a less-than-stellar season, going 6-9 in 20 starts with a 5.87 ERA. Following the season, Pignatiello retired.\n', '

On February 16, 2011, Pignatiello signed a contract with the Joliet Slammers to be their pitching coach.\n', '

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