A native of Boston, Massachusetts, Essegian attended Stanford University in Palo Alto, California. He entered the majors in 1958 with the Philadelphia Phillies, playing for them one year before joining the St. Louis Cardinals (1959), Los Angeles Dodgers (1959–1960), Baltimore Orioles (1961), Kansas City Athletics (1961, 1963) and Cleveland Indians (1961–1962). His most productive season came in 1962, when he posted career numbers in batting average (.274), runs (59), hits (92), doubles (12), home runs (21), runs batted in (50) and games played (106).\n', '

In a six-season career, Essegian was a .255 hitter (260-for-1018) with 47 home runs and 150 RBI in 1018 games.\n', '

During the 1959 World Series, Essegian set a Series record with two pinch-hit home runs against the Chicago White Sox. The mark would be matched by Bernie Carbo of the Boston Red Sox, who pinch-hit homers against the Cincinnati Reds in the 1975 Series.\n', '

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