After coming out as gay in 2014, Franzese became more active in the fight for civil and human rights in the LGBTQ community; and through his portrayal of the HIV-positive character Eddie in the second season of the HBO series Looking, and its subsequent series finale television film, Looking: The Movie, he has become a well known AIDS activist in the United States. In 2015, he became an ambassador for the Elizabeth Taylor AIDS Foundation.
In 2020, Franzese began hosting a weekly comedy and faith podcast, Yass, Jesus! with former Trinity Broadcast Network host Azariah Southworth.
Franzese was born in Bensonhurst, Brooklyn, New York, the son of Denise, a cafeteria worker, and Ralph "R. J." Franzese, a lounge singer. Franzese attended Piper High School in Sunrise, Florida from 1992 to 1996. He is of Italian descent.

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