Ramirez was born in Chicago and raised in Miami. He is of Colombian and Mexican descent. He attended Miami Coral Park Senior High School. Growing up he wanted to be an athlete and he tried American football and soccer. He says that after encountering injuries it took him a year to realize he would need a new career.
Danny Ramirez made his television debut on Showtime's, The Affair followed by roles on NBC's Blindspot and the feature film, Rapid Eye Movement while attending New York University's Tisch School of the Arts.
He played a reoccurring role as Wes on Fox's The Gifted and he was Mario Martinez on the hit Netflix series On My Block. He also guest-starred in Orange Is the New Black. His first notable film credits came shortly after graduating in Sam Levinson's Assassination Nation which premiered at the Sundance Film Festival. He was Chip shortly after that in Metro-Goldwyn-Mayer's remake of the musical Valley Girl.

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