Kile was selected by the Houston Astros in the 30th round of the 1987 Major League draft. Having been successful with the Tucson Toros, the Astros\' AAA club in the Pacific Coast League, Kile entered the majors in 1991, going 7–11 in 22 starts. In his first major league start on April 24, 1991, Kile had a no-hitter going when he was lifted after six innings by manager Art Howe, who wanted to protect the 22-year-old rookie\'s arm. Kile\'s breakthrough year came in 1993 when he went 15–8 with a 3.51 earned run average and made the All-Star team. On September 8, Kile pitched a no-hitter against the New York Mets. He pitched seven seasons with the Astros, mostly as a starter. Another strong season was 1997, when he went 19–7, compiled a 2.57 ERA, made the All-Star team again, threw a career-high ​255 2⁄3 innings, and pitched four shutouts. He finished fifth in voting for the NL Cy Young Award. Kile made his first postseason appearance in Game 1 of the 1997 National League Division Series against the Atlanta Braves, giving up only two hits but suffering a hard-luck 2–1 loss. Atlanta swept Houston in the best-of-five series.\n', '

In 1998, Kile signed with the Colorado Rockies as a free agent. Kile suffered control problems, allowing hitters to lay off his curveball. After two seasons in which he was a combined 21–30 and posted ERAs of 5.20 and 6.61, Kile was traded to the Cardinals. In his first season with St. Louis, Kile went 20–9, becoming the first Cardinal pitcher since John Tudor and Joaquín Andújar in 1985 to win 20 games in a season. He made his third All-Star team and again finished fifth in NL Cy Young Award voting. He earned the first playoff victory of his career in Game 2 of the 2000 NLDS against Atlanta, but suffered two losses in the NL Championship Series, which the Cardinals lost to the Mets in five games.\n', '

Kile went 16–11 in 2001, and the Cardinals made the playoffs again, losing to the eventual world champion Arizona Diamondbacks in the NLDS. (Kile got a no-decision in his Game 3 start). Kile threw ​227 1⁄3 innings and compiled a 3.09 ERA that season, despite having an injured shoulder which required surgery after the Cardinals were eliminated from the playoffs. He spent the offseason rehabilitating and was ready for the start of the 2002 season. In 12 seasons as a major league pitcher, Kile never went on the disabled list.\n', '

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