In 1988, Moscow played the young Josh Baskin in Big, in which his character was magically transformed into an adult played by Tom Hanks. Moscow landed the role of David Jacobs in the 1992 filmed version of the musical Newsies, co-starring opposite Christian Bale. Moscow also appears in a leading role opposite Jessica Alba in the film Honey and has starred on several network television series including Zoe, Duncan, Jack & Jane. He was also featured on the television series Seinfeld as the character Lomez Jr in the episode "The Van Buren Boys".
He has also appeared in leading roles on Broadway, including Artie in the production What's Wrong with This Picture at the Brooks Atkinson Theatre. Moscow ran A Theater Co. in New York alongside actors Tom Everett Scott and Michael Kelly.[citation needed]
Moscow also co-developed and co-produced Lin-Manuel Miranda's first production of In the Heights with his ex-fiance, actress Kerry Washington.

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