May was born in Remington, Indiana.
May has appeared in a number of television shows during her career, include the major recurring role as Terri Valere on the NBC medical drama St. Elsewhere (1985–86). Other television credits include Falcon Crest, Remington Steele, The Golden Girls, Star Trek: Deep Space Nine, Star Trek: Voyager, Murder One, The Larry Sanders Show, Seinfeld (episode "The Puffy Shirt"), and ER.
In 2010, May had a recurring role as Catherine Cadence in the British television series The Cut.

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