Qualls was born in Nashville, Tennessee, one of five children of Donnie and Debbie Qualls. He was raised in Manchester, Tennessee, and attended school nearby. He was diagnosed with Hodgkin\'s lymphoma at age 14; after two years of treatment, his cancer was said to be in remission. According to Qualls the chemotherapy he received at an early age sped up his metabolism and impacted his system at a time of growth, "It stopped my development," which explains his slender frame. After graduating from Coffee County Central High School, where he was an active member in the Red Raider Band, Qualls attended King\'s College, London, where he studied English language and English literature. He returned to Tennessee and enrolled in Belmont University in Nashville, where he also began acting in a local theater company.\n', '

Qualls was an extra in the 1994 HBO film Against the Wall. He landed the small role of Jason in the miniseries Mama Flora\'s Family (1998) while participating in community theater. After auditioning for a one-liner in Road Trip (2000), he was asked to come from the Atlanta office to meet producer Ivan Reitman in California. He debuted in Road Trip as shy virgin Kyle Edwards. After this, he worked as a model for Prada and photographers such as David LaChapelle and Steve Klein. In Cherry Falls (2000), he played Wally, another virgin. In 2001, he played Neil Lawrence in Chasing Holden. Qualls also appeared as a Y2K prophet opposite of Rami Malek in the sci-fi mystery thriller Buster\'s Mal Heart (2017). \n', '

In 2002, Qualls played Archie in the film Comic Book Villains, Andrew in the film Big Trouble, Junior in the film Lone Star State of Mind, Dizzy Gillespie Harrison in the film The New Guy, and Rat in the sci-fi film The Core. He starred in the comedy Delta Farce. In 2005, he appeared as Shelby in the film Hustle & Flow. His television work includes eccentric hunter Garth Fitzgerald IV on Supernatural and appearances on Monk, Scrubs, Criminal Minds, Lost, Law & Order: Criminal Intent, CSI, Numb3rs, My Name Is Earl, Breaking Bad, The Big Bang Theory, and Memphis Beat.\n', '

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