Born in Winston-Salem, North Carolina, Cardwell signed with the Philadelphia Phillies as an amateur free agent in 1954.\n', '
Cardwell began playing in the major leagues when he made his debut for the Phillies in 1957. He struggled during his three seasons with the team, winning 16 games while losing 24 as a spot starter. \n', '
Cardwell was traded to the Cubs on May 13, 1960, for Tony Taylor. Two days later, he no-hit the St. Louis Cardinals 4–0 in the second game of a doubleheader at Wrigley Field—the first no-hitter ever thrown by a pitcher in his first start with a new team. The lone baserunner for the Cardinals was by a walk from Cardwell to Alex Grammas with one out in the first inning; Cardwell then retired the next 26 batters. Two ninth-inning catches enabled Cardwell to secure the no-hitter: the first catch by Cubs right fielder George Altman on a Carl Sawatski line drive for…
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