Wilkes is perhaps best known for her starring role in the thriller Angel (1984), in which she portrayed a preparatory student in Los Angeles who lives a double life as a prostitute by night. Her other credits include the horror film Grotesque (1988), opposite Linda Blair and Tab Hunter, and guest-starring roles on the series Dragnet (1989) and FBI: The Untold Stories (1991).
Wilkes abandoned her acting career in the early 1990s after the birth of her daughter. She returned to acting in 2013, appearing in the independent films My Stepbrother Is a Vampire!?! and 90210 Shark Attack (2014).
Wilkes was born in Manhattan, New York City in Spanish Harlem. Her father was Wayman Otis Wilkes (1918–2013), an Irish American chiropractor originally from Texas, while her mother, a nightclub singer from El Salvador, was of Spanish and French descent. Wilkes's parents divorced when she was 3 months old. She was raised speaking both English and Spanish, and is fluent in both.

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