Mathis attended Show Low High School in Show Low, Arizona. He was drafted by the Los Angeles Dodgers after his senior year. He did not sign with the Dodgers, but instead attended Central Arizona College in Coolidge, AZ. After his first year at Central Arizona, Mathis was drafted in the 31st round by the Seattle Mariners. He declined once again and decided to attend the University of Missouri. After one year, he was drafted by the Rangers and signed a minor league contract.\n', '

In 2006, Mathis played for the Advanced A Bakersfield Blaze and was California League Pitcher of the Week twice. In 2007, he was Texas League Pitcher of the Week twice and was a mid-season all-star for the AA Frisco RoughRiders. Mathis began the 2008 season with the AAA Oklahoma City RedHawks and was called to the majors in May. Mathis made his major league debut with the Rangers on May 12, 2008, when he entered the game against the Seattle Mariners in the 10th inning and was the winning pitcher in the Rangers\' 13–12 victory. During the early part of the 2010 season, Mathis was sent down to the minor leagues, where he continued to struggle getting batters out.\n', '

On January 5, 2011, he signed a minor league contract with the Cleveland Indians. He was later released by Cleveland and signed a minor league contract with the San Francisco Giants before being released by them. Mathis then signed a minor league contract with the Oakland Athletics on June 18.\n', '

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