Sandra Siew Pin Lee was born in the Flushing section of Queens, New York, on December 20, 1970, to ethnically Chinese parents; her father, a retired dermatologist, is Singaporean while her mother is Malaysian. Her parents migrated to New York in 1969, and the family relocated to Southern California when Lee was five years old.
Lee attended UCLA as an undergraduate student. During this time, she worked part-time as a medical assistant for an allergist in Downtown Los Angeles. After her graduation from UCLA, Lee attended medical school at the Drexel University College of Medicine and graduated in 1998. She completed her internship at Allegheny General Hospital in Pittsburgh. Lee completed her dermatology residency at Southern Illinois University. After her residency finished, she went to San Diego to further her experience with laser, dermatological and cosmetic surgery. Lee now lives in Upland, California with her husband, fellow dermatologist Jeffrey C. Rebish (married May 28, 2000), and currently works at Skin Physicians & Surgeons.
Lee is a board certified dermatologist and a member of the American Academy of Dermatology, the American Academy of Cosmetic Surgery, the American Society for Dermatologic Surgery, and the American Society for Mohs Surgery.

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