He made his big league debut on September 15, 1920 at the age of 27. Facing the Boston Red Sox, he came into the game as a replacement player for Baby Doll Jacobson, going 0-2 at the plate. Two days later, on September 17, he collected his first career hit. Overall, he hit .429 in seven games in 1920, walking four times and striking out only once in 21 at-bats.\n', '

In 1921, Wetzel played in 61 games for the Browns, hitting .210 in 119 at-bats. Through the month of April that year his average was .364; however it steadily declined from that point. Of his 25 hits, two were doubles and two were home runs. He played in his final big league game on October 2, 1921.\n', '

Overall, Wetzel hit .243 in 68 major league games, collecting 34 hits in 140 at-bats. He scored 21 runs and drove 15 runs in.\n', '

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