Klepfer, commonly known as "Big Ed", was born on March 17, 1888 in Summerville, Pennsylvania. He batted and threw right-handed and was also 6 ft 0 in (1.83 m), 180 pounds, and attended Penn State University.\n', '

Klepfer made his big league debut on July 4, 1911 with the Highlanders. His career was chopped up due to time spent fighting in World War I, as part of the American Expeditionary Forces in France. At one time in his war fighting tenure, he was gassed.\n', '

Perhaps the most extraordinary part of his career was his second to last season-1917. He went 14–4 with a 2.37 ERA in 213 innings. He finished his career with a 22–17 record and a 2.98 ERA in 98 games.\n', '

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