Santana signed with the Pittsburgh Pirates as an international free agent in October 2013. He made his professional debut in 2014 with the Dominican Summer League Pirates and spent the whole season there, going 1–3 with a 3.66 ERA in 19.2 relief innings pitched. He played 2015 with the West Virginia Black Bears and West Virginia Power where he posted a combined 1–0 record and 3.19 ERA in 22 relief appearances. In 2016 he pitched for the Bradenton Marauders, Altoona Curve and Indianapolis Indians, compiling a combined 4–1 record and 2.71 ERA in 43 appearances out of the bullpen, and after the season pitched in the Arizona Fall League. \n', '

Santana started 2017 with the Indianapolis Indians, and was called up to the Pirates on June 10. He made his MLB debut that day against the Miami Marlins, in which he pitched an inning, allowing one run on three hits and striking out two. He was recalled and optioned multiple times during the season. In 44 games for Indianapolis he was 1–3 with a 2.79 ERA, and in 19 games for the Pirates he compiled a 3.50 ERA.\n', "

Santana began 2018 in Pittsburgh's bullpen.\n", '

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