Wickersham has Austrian and Swedish (Värmland) ancestry. She was born in Kansas but grew up in Mamaroneck, New York. She attended Muhlenberg College for two years before dropping out.\n', '

In 2013, following the departure of actress Cote de Pablo, Wickersham was cast as NSA Analyst Eleanor "Ellie" Bishop in a three-episode arc on NCIS, starting November 19, 2013, on CBS. She was subsequently promoted to series regular. Wickersham has also appeared in the feature film Gone and made a number of guest appearances on television.\n', '

She married musician Blake Hanley on November 23, 2010, on Little Palm Island in the Florida Keys. Currently single after separation in 2018.[citation needed]\n', '

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