Reign is from St. Louis, Missouri. Growing up, she performed in school plays and community theatre productions.
In 2019, she starred in Tourmaline's short film Salacia, about the transgender woman Mary Jones. The film is now part of the Museum of Modern Art's permanent collection. In 2021, Reign was mentored by Tourmaline through the Queer|Art|Mentorship program.
Reign made her film debut as Kelsa in Ximena García Lecuona's and Billy Porter's 2022 American coming-of-age romantic comedy film Anything's Possible, which premiered on Amazon Prime Video in July 2022. She accompanied Porter to the 75th Tony Awards in June 2022.
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