Castillo began his professional career as a starting pitcher in 2006, playing for the Dominican Summer Rangers and AZL Rangers, going a combined 1-4 with a 3.10 ERA in eight games (seven starts). That year, he struck out 41 batters in 29 innings. In 2007, Castillo went 3-5 with a 5.92 ERA in 14 starts for the Spokane Indians, allowing 73 hits in 62 1/3 innings.\n', '

He converted to relief pitching in 2008, going 2-5 with a 5.28 ERA in 36 games (seven starts) for the Clinton LumberKings. In 2009, he went 3-6 with a 4.05 ERA in 40 games (two starts) for the Hickory Crawdads. He split 2010 between the Bakersfield Blaze and Frisco RoughRiders, going a combined 1-3 with a 2.11 ERA in 39 relief appearances. He struck out 67 batters in 55 1/3 innings. In 2011, he was 3-6 with a 6.36 ERA in 42 games for Frisco and in 2012, he was 4-1 with a 3.54 ERA in 35 games for Frisco and the Round Rock Express. \n', '

He pitched in the San Francisco Giants system in 2013 and went 6-7 with a 5.34 ERA in 37 games between the Richmond Flying Squirrels and Fresno Grizzlies. \n', '

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