He was signed by the Houston Astros as an amateur free agent in 1995 and drafted by the San Francisco Giants from Houston in the 2001 Rule 5 Draft. Later, he was selected off waivers by the Tampa Bay Devil Rays in 2002, making his major league debut in that season. In 2003, Escalona was claimed off waivers by the Baltimore Orioles, but did not play in the majors for them.\n', '

In 2004, Escalona signed a minor league contract with the New York Yankees and was invited to spring training. He started the season with the Triple-A Columbus Clippers and was recalled to the majors in September. Escalona was released by the Yankees during the 2006 season.\n', '

In 2008, Escalona signed with the Ottawa Rapidz of the Can-Am League, but was released on July 6, 2008.\n', '

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