Floriana was born in Cincinnati, Ohio, the daughter of Dennis Lima and Angela Maynard. She is of Italian, Irish, English, Spanish and Portuguese descent. She graduated from Fairfield Senior High School in 1999 and went on to study Communications at Ohio State University.
After college, she worked as a production assistant at NBC affiliate WCMH-TV in Columbus, Ohio. She then decided to move to Los Angeles to pursue an acting career.
Lima was a series regular in the internet comedy Poor Paul (2008-2009) and later became a series regular in Fox's medical drama The Mob Doctor (2012-2013). She had a recurring role in NBC's spy series Allegiance (2015), was a series regular in ABC's thriller The Family (2016) and had a recurring role in Fox's action drama Lethal Weapon from 2016 to 2018. From 2016-2017, Lima played lesbian Detective Maggie Sawyer in season two & three of The CW's Supergirl.

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