Reale was born and grew up in Los Angeles and received a BFA in acting at New York University. She also studied at the Lee Strasberg Theatre and Film Institute and Stonestreet Studios. She received a 2012 National Youth Arts Award for Outstanding Youth Choreography for "Bordan vi Haller" in Winter Dance Concert, Hamilton Academy of Music.
Reale appeared for two seasons in 2016 and 2017 in the Netflix original series Haters Back Off, in which she played the supporting role of Emily, Miranda’s sister. In 2016 she also played Gabriella Moretti in the episode "Down the Rabbit Hole" on the television series Blue Bloods.
She played the recurring role of Heather, a lifeguard, on season 3 of Stranger Things, a Netflix original series, where her character is "the centerpiece of a dark mystery." She plays Laura in the 2019 comedy film Yes, God, Yes.

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