Tepedino was drafted by the Baltimore Orioles on June 8, 1965, in the third round of the 1965 amateur draft. He was then drafted from the Orioles by the New York Yankees on November 28, 1966 in the 1966 first-year draft. \n', '

Tepedino made his major league debut on May 12, 1967 with the Yankees in a game against Orioles at Yankee Stadium, with 22,300 in attendance. He pinch hit for Whitey Ford in the bottom of the third inning of a blowout, and popped out to shortstop. The Yankees lost the game by a score of 14–0.\n', '

On June 7, 1971, the Yankees traded Tepedino and Bobby Mitchell to the Milwaukee Brewers for Danny Walton. On March 31, 1972, he was repurchased by the Yankees from the Brewers, and on June 7, 1973, traded again, with Wayne Nordhagen and players to be named later, to the Atlanta Braves for Pat Dobson. To complete the trade, the Yankees also sent Dave Cheadle on August 15, 1973 and Al Closter on September 5, 1973 to the Braves.\n', '

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