A power-throwing left-hander, Morales made his Major League debut on August 18, 2007, against the Los Angeles Dodgers. He pitched 5​1⁄3 innings, gave up one run, but got a no-decision. In 2007, Morales was selected to the All-Star Futures Game at AT&T Park in San Francisco. Morales made 8 starts in 2007 going 3-2 with a 3.43 ERA. He was also part of the Rockies\' 25-man active roster for the postseason where the team went to the World Series for the first time ever but lost to the Red Sox in a 4-game sweep.\n', '

On April 29, 2008, Morales was optioned to the Colorado Rockies Triple-A affiliate, the Colorado Springs Sky Sox in response to a sub-par performance during the early 2008 Major League season. During the 2008 season, he made 5 starts going 1-2 with a 6.39 ERA in the Majors.\n', '

In spring training in 2009, Morales led all pitchers in pickoffs, with 5, in 28 innings.. He began the regular season in the starting rotation, but after struggling early he was optioned to the Triple-A Colorado Springs Sky Sox. He was called back up and has been pitching from the bullpen since July 7. In 2009, Morales made 40 appearances (2 starts) going 3-2 with a 4.50 ERA.\n', '

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